The Czech Republic, like other countries of Central and Eastern Europe, has undergone the first full EU programming period, the period 2007 – 2013. All cohesion policy interventions aimed at reducing regional disparities were completed in 2015, according to the n+2 rule. Impact assessment of programs and projects were in the forefront of EU institutions, individual governments and regions. This article aims to evaluate impacts of public support on a tourism area in the selected Southwest NUTS II region in the Czech Republic. Statistical methods, qualitative research, Counterfactual Impact Evaluation (CIE) methods and principles of theory-based impact evaluation are used for the impact assessment. When evaluating the impact of interventions in tourism in the Southwest NUTS II region it was found, from a methodological point of view, that the major barrier to the use of Counterfactual Impact Evaluation methods was poor accessibility and especially quality of data. The evaluation shows that benefits are observable in terms of specific projects or locations, but cannot be seen in the larger territory of a NUTS II region. Here it is evident that tourism is a sensitive segment of the national economy mainly reactive to the economic situation in source countries, the peace situation in the world and, of course, to the purchasing power of the population.