This article deals with analysis of demographic data for component regions in the Czech Republic in 2015. Out of the source demographic data of the Czech Statistical Office there were calculated basic indicators, measures and demographic indexes. Using the Principal Component Analysis an extensive number of variables was eliminated to five crucial components which were subsequently included in the targeted Cluster Analysis. On the basis of the Ward method of hierarchic clustering and application of Euclid distance calculation, the probability matrix was compiled to get the resultant dendrogram of the four main clusters. Among other it was found out that region of the capital Prague (Hlavní město Praha) creates separate cluster together with Pardubice, and Central Bohemia (Středočeský) region create separate cluster with Liberec region.